The chemical substances and active drug combine together to form a medical drug. This process involves the production of drug which characterized by stability and acceptable to the patient. Besides that in case of synthesis of an oral medication (tablet or capsule)contains a variety of ingredients besides the drug itself; it is an obligation to be sure that all of these ingredients must be incorporated with each other. It is important to do a lot of formulation studies in order to detect the point of incorporation. Besides, that formulation studies must focus on other factors like particle size, polymorphism, pH, and solubility, in order to check whether these factors will affect the bioavailability of the drug or not.