Track 16:Other Screening Techniques

Other Screening Techniques: The following are some other Approaches to The Experimental Pharmacology.

Avian chick embryo model: Utlization of chick models for Genetic Manipulation is continued. The further studies include, Time Lapse Video Microscopy, knockout studies, TALENs, CRISPRs, Zinc-Finger nuclease technology

Stem cell models: Lund Human Mesencephalic (LUHMES) cell lines, a 3D dopaminergic neuronal model for neurotoxicity testing and Parkinson's disease (PD). Using confocal microscopy, gene expression, and flow cytometry, the 3D model was characterized and observed a highly reproducible differentiation process, which begins the further era of studying some of the diseases.

In chemico tests:

The toxic potential of some substances can sometimes be detected using relatively simple chemistry based methods and not requiring human cells or the whole cell lines. A major effort in this project is to measure in chemico reactivity. The HPLC and Direct Peptide Reactivity Assay (DPRA) are some of the well established techniques.

Subtracks:

1. Pyrogen tests

2. Monocyte-Activation Test

3. Limulus Amebocyte Lysate (LAL) test

4. Carcinogenicity Testing

5. Cell transformation Assays

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