Allied Academies invites all the participants across the globe to attend “World Conference on Pharmacology and Cell Line Studies” during November 29-30 2017 in Atlanta, USA which includes prompt Keynote presentations, Oral talks, Poster presentations and Exhibitions.
This World Conference of Pharmacology focuses
on the importance to understand drugs therapeutic, Cell Line Development and alternatives in the Research and Teachings, thus how can we maximize the use of cell line models and also various other monitoring aspects in research and development. It is with better understandings not only one can know the traditional methods of pharmacology but also the Clinical Trails and Experimental approaches in research without the usage of animals and on the other hand with the use of Cell Line models. More
research in pharmacology deals with identifying and research in Drug Development, Cell Line Preservation and usage in the long run, in vitro, in silico models, non invasive techniques, micro-dosing. More interestingly the Traditional ways of Pharmacology and the bio technology research now resulting in the Advancement and new Trends.
Join us in Atlanta, USA for the World Conference on Pharmacology and Cell Line Studies
Find the latest developments and new strategies in New Era : A Bottom Line Research and Development, such as Drug Development, new Drugs innovation, Ethanopharmacology, Stem cell, Cell line developments, Neuropharmacology, Cancer pharmacology, Molecular Pharmacology, Invertebrate models. QSAR based Studies, and many related topics of Pharma research and new innovation in the research of academic, research centers and industrialization of the pharmacology and biotech.
Who can attend our conference?
Doctors & Nurses
Associations and Societies
Manufacturing Medical Devices Companies
Directors of Association and Societies
Why to attend??
Pharmacology 2017 is dedicated to provide a premier technical forum for reporting and learning about the latest research and development, along with discussing new applications and technologies. Events include hot topics presentations from all over the world and professional networking with industries, leading working groups and panels. Allied Academies cluster is ready to prepare Pharmacology, Therapeutics and Cell Line database, this year with a read to reinforce analysis and promote awareness aiming in developing solutions for the challenges encountered. Pharmacology 2017 can comprise of the many leading keynote speakers and session speakers delivering their speech on the present analysis topics of Pharmacology, Cell Line Studies and their different research strategies, Clinical and Experimental Trails and facet effects. The young researchers and also the student participants can gain the chance to grab the most effective Poster Award by presenting their work as a billboard presentation and Young research Forum
Make remarkable attendance around the world focused on learning about Pharmacology, Experimental Pharmacology, Invitro, Invivo approaches Cell line studies and related advances, which is your single best opportunity to reach the largest assemblage of participants from the Pharmacology and Bio tech community, conduct demonstrations, distribute information, meet with current and potential professionals, make a splash with a new research works, and receive name recognition at this 2-days event. World-renowned speakers, the most recent research, advances, and the newest updates in Pharmacology and Related fields are hallmarks of this conference.
- 200+ Participation (40% Industry, 50% Academia, others 10)
- 5+ Keynote Speakers
- 50+ Plenary Speakers
- 20+ Exhibitors
- 14 Innovative Educational Sessions
- 5+ Workshops
- B2B Meetings
- Make sales
- Debut new products
- Profile your brand
- Meet new business partners and suppliers
- Develop key relationships
- Educate healthcare, dentists, dental institutions and academia
Conference Main Topics & many related sub-topics
Cell Line Development
Clinical and Experimental Pharmacology
Stem cell Models
Organ on chip Models
Allied Academics Welcomes all the attendees, speakers, sponsor’s and other research expertise from all over the world to the World Conference on Pharmacology and Cell Line Studies (Pharmacology -2017) which is going to be held during November 29-30, 2017, in Atlanta, USA . We are very much honored to invite you all to exchange and share your views and experience on New Era: A Bottom Line Goals to Contemporary World, Pharmacology -2017.
Allied Academics Organizes Pharmacology -2017 along with 300+ Conferences across USA, Europe & Asia every year with support from 1000 more scientific societies and Publishes 400+ Open access journals which contains over 30000 eminent personalities as editorial board members.
We invite you to join us at the Pharmacology -2017, where you will be sure to have a meaningful experience with scholars, Veteran Scientists, Doctors, Pharmacists, Bio technologists, from around the world. All members of the Pharmacology -2017 organizing committee look forward to meeting you in Atlanta USA.
Pharmacology is the branch related with the study and results of drug action, where a drug is widely defined as any man-prepared, natural, or endogenous molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism (sometimes the word pharm cone is used as a term to encompass these endogenous and exogenous bioactive species).It deals with the ADME process of any pharmaceutical Drugs. The field includes tranquilize piece and properties, union and medication outline, atomic and cell components, organ/frameworks instruments, flag transduction/cell correspondence, communications, toxicology, compound science, drugs, treatment, medicinal applications and many related topics.
Drug legislation and Safety
Research scope in Pharmacology
2) Cell line studies:
A cell line is a permanently established cell culture that will be useful indefinitely, given appropriate clear medium and space for the cells to grow. Cell lines are often used in place of primary cells to study biological processes. Cell lines provide a pure population of cells, which is valuable since it provides a consistent sample and reproducible results. Cell lines have revolutionized scientific research and are being used in vaccine production, testing drug metabolism and cytotoxicity, antibody production, study of gene function, generation of artificial tissues. However, despite being a powerful tool, one must be careful when using cell lines in place of primary cells. Cell lines should display and maintain functional features as close to primary cells as possible. Therefore, it has to be noted that cell lines do not behave identically with primary cells and should not be used to replace primary cells. In order to strengthen the findings, key control experiments using primary cells should always be performed.
Immortalized Cell Lines
Human Cell Lines
Applications of Genome Editing in Cell Line Development
Applications of Next-Generation Sequencing
Cancer Cell Lines
3) Clinical Pharmacology:
Clinical pharmacology is the science of drugs and their clinical use and also it connects the gap between medical practice and laboratory science. The main objective is to promote the safety of prescription, maximize the drug effects and minimize the side effects. It is that important that there should be association and team or group with pharmacists skilled in places of drug information, medication safety and other aspects of pharmacy practice related to clinical pharmacology .Receptor theory is the application of receptor models to explain drug behavior. Receptor theory for drug effects and results and its discovery and observations with clinical pharmacology has stretched out to be a multidisciplinary field and has contributed to the findings of drug interaction, therapeutic effectiveness and safety.
1. Therapeutic Drug Monitoring
2. Drug Development
3. Clinical and Forensic Toxicology
Neuropharmacology is the study and research of drugs which affect cellular function in the Neuro system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: Behavioral and Molecular. Both of these fields have been closely connected, since related with the interactions of various Neuro-transmitters, Neuropeptides, Neurotransmitters, Neuro-hormones, Neuromodulators, enzymes, secondary messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral CNS.
1. Future Aspects of Neuropharmacology
2. Clinical Neuropharmacology
3. Neurochemical Interactions
4. Neurogenesis and Repair
5. Behavioral Neuropharmacology
The knowledge of Ethanopharmacology, its holistic and systems approach which is supported by experiential base can serve as an innovative and powerful discovery engine for newer, safer and affordable medicines. Ethno pharmacology is a highly diversified approach for drug discovery which involves the observation, description and experimental investigation of indigenous drugs and their biologic activities that is based on botany, chemistry, biochemistry, pharmacology, and other disciplines (anthropology, archaeology, history, and linguistics) contributing to the discovery of natural products with biologic activity. Ethno pharmacology is a holistic approach to drug development, using the latest technology for measuring as many different parameters as possible to discover possible leads to the mode of action with ethno botanists, ethno pharmacologists, physicians and phytochemists playing a key role.
1. Integrative pharmacological investigations
2. Toxicological issues with Ethanopharmacology
3. Ethnopharmacological perspectives from traditional to modern pharmaceuticals
4. Latest trends in Ethnopharmacology
6) Drug Interaction:
A Drug interaction is an interaction between a drug and some other substance, such as another drug or a certain type of food, which prevents the drug from working correctly. Interactions should always be considered in the differential diagnosis of any unusual response occurring during drug therapy. Early detection could enable reconsideration of the culprit treatment regimen and prudent management if they do lead to adverse events. The fact that two drugs share a common metabolic pathway does not mean they will have a clinically significant interaction when co-administered; the interaction being dependent upon various factors including relative affinities of each drug.
1. Adverse Drug Reaction
2. Drug – Drug Interaction
3. Drug – Food Interaction
4. Drug – Receptor Interaction
5. Drug - Herb Interactions
Toxicology is the scientific study of adverse effects occurring in living organisms due to chemicals and drugs. It involves observing and reporting symptoms, mechanisms, detection and treatments of toxic substances, in particular relation to the poisoning of humans. Computer modeling and simulation is an example of alternative testing methods for Toxicology; using computer models of chemicals and proteins, structure-activity relationships can be determined, and chemical structures that are likely to bind to, and interfere with, proteins with essential functions, can be identified. This work requires expert knowledge in molecular modeling and statistics together with expert judgment in Chemistry, and Toxicology.
2. Clinical Toxicology
3. Immune Toxicology
4. Toxicity Testing
8) In vitro techniques:
In vitro techniques are conducted mainly by using components of an organism that have been isolated from their usual biological surroundings such as microorganisms, biological molecules, or cells. Specially called "test-tube experiments", these studies in biology and its sub disciplines are traditionally done in lab ware such as test tubes, flasks, Petri dishes, and micro titer plates. In vitro studies permit a species-specific, simpler, more convenient, and much more detailed analysis than can be done with the whole organism. Just as studies in whole animals more and more replace human trials, so are in vitro studies replacing studies in whole animals. In pharmacology, In vitro techniques can be used to approximate pharmacokinetics (PK) or pharmacodynamics (PD). Since the timing and intensity of effects on a given target depend on the concentration time course of candidate drug (parent molecule or metabolites) at that target site.
3. Primary Cell Cultures
4. Established Cell Lines
5. Cell Lines
A recent vertebrate model, the Zebra fish has proven to a very good model for toxicity testing. Studies on various chemicals have shown that Zebra fish have shown that 90% of these produced specific tissue, organ and behavioral toxicity. These have been used and validated in large scale high throughput screens for various psychotropic drugs. Their use has increased in the past two decades and a population-based atlas of the zebra fish brain has recently been developed. Zebra fishes develop rapidly, are small, inexpensive to maintain, in large numbers. Chemical administration can be done directly to fish water or by microinjection of small amounts of chemicals. The morphological and molecular basis of tissue and organ development are, in general, either identical or similar to other vertebrates including man. It has a nearly transparent body during early development, which helps easy visual access to the internal anatomy. The optical clarity allows direct observation of developmental stages, identification of phenotypic traits during mutagenesis, easy screening, assessment of endpoint of toxicity testing and direct observation of gene expression through light microscopy. Small size, short life cycle and high fecundity favor its laboratory use. Drug metabolism can also be studied in hydra, a eumetazoan diploblastic organism belonging to the phylum Cnidaria.
These are mechanistic models that aim to predict sensitization from mechanistic knowledge and empirical models that are aimed at predicting from a statistical perspective. These alternatives can be substituted by demonstrations using computer-simulated learning programs. Exercises in the form of graphs, tables obtained from various animal experiments can be used. Several “virtual humans” have been constructed by creating mathematical models of known human reactions. A few examples include computer models to model human metabolism, to study plaque buildup and cardiovascular risk and to evaluate toxicity of drugs. The digital frog and more recently award-winning virtual frog is available where a student can dissect a frog layer by layer.
2. Expharma and Xcology studies
11) Invertebrate animals:
Invertebrate organisms are widely used as an alternative for laboratory use of animals. They have been used to study various diseases like Parkinson’s disease, endocrine and memory dysfunction, muscle dystrophy, wound healing, cell aging, programmed cell death, retrovirus biology, diabetes and toxicological testing. Invertebrates can be used to replace the more commonly used laboratory animals. The most used invertebrate species are Drosophila melanogaster, a fruit fly and Caenorhabditis. elegans, a nematode worm. Drosophila melonogaster is a classic model used for detecting mutagenicity, teratogenicity and reproductive toxicity. Similarly, fruit flies can be useful to identify novel virulence factors or pharmacologically active compounds. These organisms have short life cycle and can be studied in large numbers, a distinct advantage over the vertebrates.
1. Amphimedon queenslandica
2. Sea Slug
Microdosing an alternative approach to study the behavior of drugs in humans through the administration of doses in low concentration, as they are unlikely to produce the complete-body effects, but high enough to allow the cellular response to be studied. It may be said as the less than one hundredth of the proposed pharmacological dose This is called a Phase zero study and is usually conducted before clinical Phase I to predict whether a drug is viable for the next phase of testing. Microdosing on Humans aims to cut short the resources spent on non-viable drugs and the amount of testing done on animals and experimental trials. Microdosing studies enable potential new drugs to be tested safely in humans using accelerator mass spectrometry. The technique has been developed commercially trials were conducted with several major pharmaceutical companies It is reported that 15 among the 20 largest pharmaceutical companies have now used microdosing as a new trend in drug development, and the use of the technique has been provisionally endorsed by both the Medicinal Agency of Europe and the Food and Drug Administration.
2. Accelerator Mass Spectrometry.
The ethical issues have posed many restrictions over the experimental use of higher model vertebrates like guinea pig, rats, dogs, monkeys etc. Therefore, use of alternative organisms has been proposed. Different model organisms are used to replace experimental animals. Saccharomyces cerevisiae is the most popular and important model organism due to its rapid growth, ease of replica plating and mutant isolation, dispersed cells, well defined genetic system and highly versatile DNA transformation system. Tetrahymenapyriformis – a ciliate protozoan being used to study the effects of anesthetics on metabolism.
1. Salmonella typhimurium
2. Escherichia coli
3. Bacillus subtilis
14) Non-invasive imaging technologies:
The term noninvasive is used to denote a procedure where no instrument is introduced into a patient's body which is the case for most imaging techniques used. Medical imaging has become a major tool in clinical trials since it enables rapid diagnosis with visualization and quantitative assessment. Imaging is able to reveal subtle change that is indicative of the progression of therapy that may be missed out by more subjective, traditional approaches. Statistical bias is reduced as the findings are evaluated without any direct patient contact. Imaging biomarkers (a characteristic that is objectively measured by an imaging technique, which is used as an indicator of pharmacological response to a therapy) and surrogate endpoints have shown to facilitate the use of small group sizes, obtaining quick results with good statistical power.
1. Magneto encephalography (MEG)
2. Magnetic Resonance Imaging (MRI)
3. Functional MRI (fMRI)
4. Magnetic Resonance Spectroscopy (MRS)
5. Positron Emission Tomography (PET)
15) Organ on chips model:
In the early phase of drug development, animal models were the only way of obtaining in vivo data that would predict the human pharmacokinetic responses. However, experiments on animals are lengthy, expensive and controversial. Therefore, imitating a human’s physiological responses in an in vitro model needs to be made more affordable, and needs to offer cellular level control in biological experiments: biomimetic microfluidic systems could replace animal testing. The development of MEMS-based biochips that reproduce complex organ-level pathological responses could revolutionize many fields, including toxicology and the developmental process of pharmaceuticals and cosmetics that rely on animal testing and clinical trials. Efforts made toward the development of micro fabricated cell culture systems that aim to create models that replicate aspects of the human body as closely as possible and give examples that demonstrate their potential use in drug development, such as identifying synergistic drug interactions as well as simulating multi-organ metabolic interactions.
2. DNA chips
16) Other Screening Techniques:
The following are some other Approaches to The Pharmacology and Cell Line Studies.
Avian chick embryo model: Utilization of chick models for Genetic Manipulation is continued. The further studies include, Time Lapse Video Microscopy, knockout studies, TALENs, CRISPRs, Zinc-Finger nuclease technology
Stem cell models: Lund Human Mesencephalic (LUHMES) cell lines, a 3D dopaminergic neuronal model for neurotoxicity testing and Parkinson's disease (PD). Using confocal microscopy, gene expression, and flow cytometry, the 3D model was characterized and observed a highly reproducible differentiation process, which begins the further era of studying some of the diseases.
In chemico tests:
The toxic potential of some substances can sometimes be detected using relatively simple chemistry based methods and not requiring human cells or the whole cell lines. A major effort in this project is to measure in chemico reactivity. The HPLC and Direct Peptide Reactivity Assay (DPRA) are some of the well established techniques.
1. Pyrogen tests
2. Monocyte-Activation Test
3. Limulus Amebocyte Lysate (LAL) test
4. Carcinogenicity Testing
5. Cell transformation Assays
17) Molecular Pharmacology:
medicine is additionally a branch of medicine that worries on molecular
basis of medicine. Molecular pharmacologists study the molecular study of
prescribed drugs and natural compounds utilized in the treatment of
diseases, and that they conjointly study diseases on a molecular basis with the
goal of developing pharmacologically active agents of molecular and cellular
level of developing host and many related issues which is helpful to next
generation. The Molecular Pharmacology & Drug
Design (MPDD) group focuses on understanding the nature of
the molecular recognition processes between drugs and
their macromolecular targets. We are interested in discovering the
determinants of these interactions, exploring how they modulate the biological
activities of the target, and in exploiting this knowledge to discover, design,
and optimize new therapeutic agents. The Division for Molecular Pharmacology
(MP) serves members applying approaches of biochemistry, biophysics, genetics,
and molecular biology to study molecular mechanisms of drug action, regardless
of the class of drug.
1. Drug receptor-effector coupling
2. Genetics & Molecular Biology
3. Molecular Pharmacology & Drug Design
18) Animal Ethics Committees and Guidelines:
Animal Ethics Committees (AECs) looks after the use of animals in research and teaching. Their role includes approving and monitoring the usage and supply of animals for these purposes of research and clinical trials. No animal research or teaching may be carried without the approval of the responsible AEC. AECs must also ensure that all activities they supervise comply with the animal research legislation and proceed accordingly. The decision to use animals in research requires critical thinking, judgment, and analysis. Using animals in research is a privilege granted by society to the research community with the expectation that such use will provide either significant new knowledge or lead to improvement in human and/or animal well-being.
The four Rs Principle are - Replacement, Refinement, Reduction, Responsibility.
Organization for Economic Co-operation and Development (OECD)
Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA)
Institutional Animal Care and Use Committees (IACUC)
Scientists Center for Animal Welfare (SCAW)
National Advisory Committee for Laboratory Animal Research (NACLAR)
List of Organizations protecting animals:
PETA (People for the Ethical Treatment of Animals) Organization
BUAV (British Union for the Abolition of Vivisection)
CAC (Citizens for Animal Protection)
Pharmacology associations in world
Indian Pharmacological Society
American Cancer Society
International Society of Stem Cell Research
American Society of Gene & Cell Therapy
International Stem Cell Society
Market Analysis for Animals Used and Killed Annually :-
The global cell line development market size was valued at USD 2.38 billion in 2014. Key growth drivers include the rising demand for monoclonal antibodies, increasing demand for effective cancer therapeutics and technological advancements introduced in this field.
Companies that dominate the global market share include Selexis SA, Lonza Group AG, Sartorious AG, GE Healthcare, Thermo Fisher Scientific Inc., European Collection of Cell Cultures (ECACC), Corning Inc., American Type Culture Collection (ATCC), WuXi AppTec Inc., and Sigma-Aldrich Corporation.
Right now, millions of mice, rats, rabbits, primates, cats, dogs, and other animals are locked inside barren cages in laboratories across the country. They languish in pain, ache with loneliness, and long to be free. Instead, all they can do is sit and wait in fear of the next terrifying and painful procedure that will be performed on them.
The market statistics show that 53% of research is on guinea pigs, hamsters and rabbits, while 11% is on dogs or cats and 8% on non-human primates. In the UK, where mice, rats, fish and birds are counted in the annual statistics, over 97% of research is on rodents, birds and fish.
According to the latest Government figures (for 2015), a total of 4.14 million experiments were completed in Great Britain during 2015. More than 600,000 animals were subjected to experiments that even the researchers considered had caused them moderate or severe suffering. Overall, 96.8% of animals used in scientific studies were mice, rats, fish or birds.
Cosmetics Testing on Animals Banned in Following Countries :-
1) European Union
5) New Zealand